Spectrum of Pathogens Isolated from Patients with Hemolytic Diseases

Samiah Hamad S. Al-Mijalli, Alshehanah Abdullah Reda and Nawaf Mohammad Alnafisi

Background and Objectives: Patients with hemolytic diseases are at higher risk of infections. Moreover, infections are significant contributors to morbidity and mortality in patients with hemolytic disease. Frequent screenings of infections, the spectrum of the organism, site of infection like blood urine sputum. Details of bacteremia must be explored and treated earliest to reduce morbidity and mortality in patients with hemolytic disease. The study has aimed to identify the prevalence of infection in patients with hemolytic disease in the Saudi population. Materials and Methods: A total of 113 samples were examined for microbial growth on six different culture media (BAP, NA, MacConkey, CAP, Salmonella Agar and PDA), At microbiology and toxicology laboratories at in Security Forces Hospital and King Fahd Medical City in Riyadh Saudi Arabia. Results: The characteristics of 113 episodes of invasive bacterial infection among patients with hemolytic diseases were examined. Salient pathogens were K. pneumoniae MDR, tissue MARSA, AFB tissue, E. coli, Pseudomonas aeruginosa, H. pylori, C. arbiran, Enterobacter cloacae, HBS Group A, H1N1, Candida albicans. The most frequent pathogen was K. pneumoniae MDR, tissue MARSA, the most frequent pathogen in the urine was K. pneumoniae and E. coli. Pathogen isolated in the sputum were Pseudomonas aeruginosa, K. pneumoniae, Acinetobacter. The most frequent pathogen in the stool was Clostridium Bacteremia was caused by tissue MARSA, S. aureus, Enterobacter, K. pneumoniae. Conclusion: Infection is prevalent in patients with hemolytic diseases. K. pneumoniae tissue MARSA, AFB, E. coli 9 (7.96%) and Pseudomonas were salient pathogens. Patients with hemolytic diseases should be investigated early and aggressively for infection.

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