Relationship of Viral Load toward Platelet Count and Hematocrit Level in DENV-2 Infection

Almurdi , Efrida , Zelly Dia Rofinda and Juane Plantika Menra

Background and Objective: Dengue is an infection caused by the dengue virus transmitted by the bite of infected Aedes mosquitoes. It evolves rapidly over a short time course and displays a wide range of clinical manifestations. Thrombocytopenia is commonly observed in patients with dengue virus infection and may contribute to complication bleeding and plasma leakage. This study aimed to identify the correlation of viral load with the platelet count and hematocrit levels in DENV infection. Materials and Methods: This study combined the molecular examination for determining the serotype of dengue virus and viral load with qPCR and hematology parameters to count of platelet and hematocrit. The correlation between the number of viral load with platelet count and hematocrit level was analyzed with Pearson’s correlation test. Results: There were significant correlations between the number of viral load with platelet count and hematocrit level (p = 0.000, r = 0.729, p = 0.029, r = 0.369, respectively). Conclusion: Platelet count and hematocrit level can be applied to predict viremia and disease prognosis in dengue infection patients.

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