IL23 mRNA Expression in Hirschsprung-Associated Enterocolitis

Nita Mariana, Andi Asadul Islam, Mochammad Hatta and Harsali Fransiscus Lampus

Background and Objective: Hirschsprung-associated enterocolitis (HAEC) is the cause of morbidity as well as mortality in Hirschsprung patients. Interleukin-23 (IL-23) is a cytokine with pro-inflammatory properties which has potential for autoimmune inflammatory responses in HAEC. Aim of this study was to investigate the IL-23 mRNA expression in patients with HAEC. Materials and Methods: Hirschsprung patients’ colon were assessed on HAEC degree based on Teitelbaum, then IL-23 mRNA expression was assessed through real time PCR examination. Result: IL-23 mRNA expression was obtained on average of 11,954 and SD of 0.772. There was a relationship IL-23 mRNA expression and HAEC degrees (p-value = 0.039, p<0.05). Conclusion: The higher expression of IL-23 mRNA, the higher the HAEC degree will be. The high expression of IL-23 mRNA in HAEC patients indicates that HAEC is an autoimmune disease.

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