Comparison of the Effectiveness of Teriparatide and Zoledronic Acid in Osteoporosis Treatment: A Meta-Analysis

Xin Zhang, Xinzhong Xu, Chun Zhang, Chungui Xu, Fei Huang and Wukun Xie

Background and Objective: Osteoporosis (OP) is a systemic metabolism-related complication associated with lowering the mass of bone, the altered microstructure of bone, decreased bone tissue capacity, high fragility of bone and prone to systemic fractures. This meta-analysis is intended to assess the effectiveness of TPTDand ZOLin treating osteoporosis. Materials and Methods: The 8 databases that are related to the controlled clinical trials are collected. The 95% confidence interval (CI) is set for determining the relative risk or the differences of mean in this study. Moreover, the heterogeneity of obtained results was estimated using the I² in this study. Results: According to our criteria, an overall total of 6 papers have been involved in this meta-analysis. According to the six studies, the experimental group’s Bone Mineral Density (BMD) is noticeably higher than that of the corresponding untreated group (standardised mean difference (SMD): 0.12; 95% Cl: 0.07, 0.17 and p<0.01). After investigating, it is observed that the VAS-score (SMD:-0.72; 95% Cl:-1.86,0.42 and p- 0.218), Serum procollagen type I N-propeptide(PINP) (SMD: 67.71 and 95% Cl: 13.44,121.99), β-isomerized C-terminal telopeptides (β-CTX) (SMD: 0.43 and 95% Cl: 0.17,0.68) and adverse reactions (OR: 0.52 and 95% Cl: 0.25, 1.06) in this meta-analysis. Conclusion: Meta-analysis investigations demonstrated that both TPTD and ZOL are effective in OP. The TPTD showed more effectiveness than ZOL in enhancing BMD and promoting the formation of bone. However, TPTD is less effective than ZOL in inhibiting osteoclasts.

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