International Journal of Pharmacology

Volume 19 (1), 71-79, 2023


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A Study on the Therapeutic Mechanism of Liquiritin on Rats with Acute Chronic Liver Failure

Chen Xiaoyan and Cao Bin

Background and Objective: Natural drug extracts are safe and useful in some disease treatment. Liquiritin is a triterpene saponin extracted from the root of Glycyrrhiza uralensis. However, It has been unclear liquiritin’s treatment in ACLF. To investigate the effect of liquiritin on liver injury in ACLF rats and preliminarily explore the mechanism. Materials and Methods: The ACLF model was induced by intraperitoneal injection of D-galactose solution after ligation of the bile duct. The AST, ALT, TBil, PA, endotoxin, IL -6, IL-8 and TNF-α in serum were detected. The pathological morphology of rat liver tissue were observed and the expression of TLR4/NF-κB (p65) pathway related proteins in rat liver tissue was detected. The apoptosis cell number of liver tissues from different groups was evaluated by TUNEL. Results: The AST, ALT, TBil, endotoxin, IL-6, IL-8, TNF-α in serum, apoptosis cell number and the protein expression levels of TLR4, p-NF-κB (p65) /NF-κB (p65) in liver tissues were significantly increased in low, middle and high dose groups (p<0.05, respectively) while, the level of PA in serum was significantly decreased (p<0.05) and the pathological damage of liver tissue was reduced. With the increase of liquiritin dosage the levels of AST, ALT, TBil, endotoxin, IL-6, IL-8 and TNF-α in serum, apoptosis cell number and the protein expression levels of TLR4, NF-κB (p65)/NF-κB (p65) in liver tissues of ACLF rats were increased gradually (p<0.05, respectively) while the level of PA in serum was decreased gradually (p<0.05) and the pathological damage of liver tissue was also gradually reduced. Conclusion: Liquiritin can alleviate liver injury in ACLF rats via TLR4/NF-κB(p65) pathway.

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How to cite this article:

Chen Xiaoyan and Cao Bin, 2023. A Study on the Therapeutic Mechanism of Liquiritin on Rats with Acute Chronic Liver Failure. International Journal of Pharmacology, 19: 71-79.


DOI: 10.3923/ijp.2023.71.79
URL: https://ansinet.com/abstract.php?doi=ijp.2023.71.79

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