Anti-Inflammatory and Antioxidant Effects of Chrysin Mitigates Diabetic Foot Ulcers

Yubiao Liu, Fan Wang and Baoguang Chen

Background and Objective: Diabetes foot ulcer (DFU) is among the worst devastating diabetic complications, frequently leading to amputation and death. Chrysin is a potent flavonoid, with various biological activities including antidiabetic action. However, its efficacy in the prevention of wound healing in DFU is not yet documented. Therefore this study was intended to evaluate the efficacy of chrysin in healing streptozocin-induced diabetic foot ulcers (STZ). Materials and Methods: Animals were selected into four groups (n = 10) and the diabetes was induced with STZ (55 mg kg^–1). The diabetic animals were made wounds and treated with two different doses (40 and 80 mg kg^–1 b.wt.) of Chrysin. The boy’s weight, food intake, serum glucose, wound contraction rate, HbA1C levels, antioxidants and oxidative stress markers levels were measured. Further, the mRNA expression level of inflammatory markers and protein expression of growth factors were also evaluated. Results: Chrysin treatment increased the percentage of wound contraction rate, reduced the HbA1C level and increased the antioxidants and hydroxyproline level and decreased MDA and MOP activity to normal as compared to diabetic wound (DW) rats. Further, Chrysin administration attenuated the elevated mRNA levels of TNF-α, IL-6 and NF-κB mRNA to normal. In addition, the protein level of VEGF and TGF-β1 were markedly improved by Chrysin, implicating its wound healing potential. Conclusion: This study demonstrated that the administration of Chrysin could prevent DFU with enhanced wound healing potential.

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