Aqueous Extract from Sukkari Date Seeds Attenuates Neuroinflammation Induced by Type-2 Diabetic in Rats

Vasudevan Mani, Minhajul Arfeen, Sultan Sajid and Yasser Almogbel

Background and Objective: Diabetes mellitus is recognized as a global pandemic and is recently linked to cognitive and memory decline. In this study effect of Aqueous Sukkari Dates Seeds Extract (ASSE) on Type-2 Diabetes Mellitus (T2DM) associated neuroinflammation was explored. Materials and Methods: About 30 Sprague Dawley Male rats were divided into 5 groups with 6 rats each. Four groups of rats were induced with T2DM using nicotinamide and Streptozotocin (STZ), while one was considered as control. Among the 4 groups, two were treated with oral doses of 200 and 400 mg kg^–1 of ASSE, the 3rd group was treated with standard drug metformin while the 4th group was left untreated and considered as diabetic-induced. The treatment with ASSE and metformin was continued for 30 days. At the end of treatment, the brain tissue was isolated and estimated for the neuroinflammatory parameters like TNF-α, IL-6, IL-10, TGF-β1 and COX-2. Results: The 2 doses of ASSE resulted in a significant decrease of COX-2 levels besides resulting in the decrease of proinflammatory cytokines like TNF-α and IL-6 levels. The administration of ASSE also increased an anti-inflammatory cytokine, IL-10 levels. Conclusion: The results support the neuroprotective effects of ASSE. Besides, it can also be concluded that the ASSE also has the potential to improve the cognitive deficit in T2DM patients.

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