Chemoprotective Effect of Ginsenoside Against the 1,2-Dimethylhydrazine (DMH) Induced Colorectal Cancer in Rats

Xiuchun Guo, Hongxia Wang, Weigang Zheng, Chunlei Guo and Qiang Song

Background and Objective: Colorectal Cancer is the 2nd leading cause of cancer-related death among all types of cancers. Oxidative stress plays a crucial role in the expansion of colorectal cancer. Ginsenoside has a well known antioxidant agent and its proven antioxidant role against various diseases. This study analyzes the chemoprotective effect of ginsenoside against 1,2-dimethylhydrazine (DMH) induced colorectal cancer in rats. Materials and Methods: Swiss Wistar rats were used for colorectal cancer protocol. The rats were orally treated with ginsenoside. The body weight of the all-groups rats was estimated at regular time intervals. Tumour incidence, tumour weight and tumour volume were estimated. The antioxidant parameter, phase I and phase II enzymes were estimated in the hepatic and colorectal tissue. Pro-inflammatory cytokines, inflammatory mediators and proliferative parameters were estimated. Results: Ginsenoside treated rats significantly (p<0.001) boosted the body weight along with suppression of tumour weight, tumour incidence and tumour volume. Ginsenoside treated rats significantly (p<0.001) enhanced the level of glutathione (GSH), catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD) and reduced the level of TBARS in the hepatic and colorectal tissue. Ginsenoside treated rats significantly (p<0.001) altered the level of lipid parameters. Ginsenoside treated rats significantly (p<0.001) suppressed the level of inflammatory cytokines, inflammatory mediators in the hepatic and colon tissue. Conclusion: Collectively, results suggest the antioxidant, anti-cell proliferative and anti-inflammatory effect of ginsenoside against DMH induced colorectal cancer.

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