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Journal of Pharmacy and Allied Health Sciences
eISSN: 1908-2044
pISSN: 2224-2503

Editor-in-Chief:  Abdul Rohman
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Research Article
Published on March 15, 2016
Hepatoprotective Effects of Plasmodium berghei Infected Swiss Mice Treated with some Plant Extracts
A.J. Uraku
Hepatoprotective effects of ethanol leaf extract of Spilanthes uliginosa, Ocimum basilicum, Hyptis spicigera and Cymbopogon citratus against Plasmodium berghei induced malaria in Swiss mice were investigated. Eighty four swiss mice of both sexes were used. All the mice were infected intraperitoneally with 0.2 mL parasitized blood suspension and parasitemia assessed by Giemsa stain thin blood films after three days (72 h). The mice were divided into 6 groups namely; A, B, C, D, E and F. Groups B, C, D and E were subdivided into three: B1, B2, B3, C1, C2, C3, D1, D2, D3, E1, E2 and E3. Both groups and subgroups contained six mice each. The subgroups were treated with the extracts of Spilanthes uliginosa (Sw), Ocimum basilicum, Hyptis spicigera and Cymbopogon citratus each for five consecutive days with 200, 400 and 800 mg kg–1 b.wt., via oral intubation once daily. The results indicated a general significant (p<0.05) decrease in the average body weight of the parasitized untreated mice and a dose dependent significant reductions (p<0.05) in the activities of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) in parasitized treated mice. Dose dependent significant elevations (p<0.05) were observed in total protein and albumin concentrations of parasitized treated mice. The results suggest that these plants possess hepatoprotective potential.
Research Article
Published on March 15, 2016
Assessment of Pharmaceutical Service Quality Provided in Bishoftu General Hospital and Community Pharmacies at Bishoftu, Eastern Shoa, Ethiopia
Kibru Sime Kebede, M.N.S.V.V.R.M. Vijaya, Magharla Dasaratha Dhanaraju and Thirumurugan Gunasekaran
Activities of pharmacists and quality of pharmaceutical services given in Bishoftu General Hospital (BGH) and 13 Community Pharmacies (CP) in Bishoftu town, Ethiopia were assessed. A cross-sectional study was conducted to all pharmacists working in Bishoftu town, Oromia State, Ethiopia during March 15 to April, 30 2014 by interview through self- structured questionnaires and participation observations of the dispensing process. A Total of 55 (100%) pharmacists were participated. Out of which 13 (23.6%) of respondents were from BGH and 42 (76.4%) were from CP. Computer 13 (100%) and leaflets 23 (54.8%) were the main sources used for updating drug information. Most of pharmacists made discussion with prescribers 10 (76.9%) and simply dispense 32 (76.2%) and 6 (46.2%) and 7 (16.7%) of pharmacists made a correction to occur errors in hospital and CP, respectively. The availability of drug information updating sources was rarely found in CP and the number of pharmacists in CP was little number when compared to hospital pharmacy. The main causes for a dispensing error for both hospital and community pharmacists were unclear prescription from the prescriber.
Research Article
Antioxidants and Antimicrobial Activities of Methanol Extract of Newbouldia laevis and Crateva adansonii
Tsado A. Ndarubu, Lawal Bashir, Ossai P. Chukwudi, Jagaba Aliyu, Gwadabe N. Kontagora, Jiya A. Gboke, Umar A. Muhammad and Oladunjoye J. Olabode
Plants and plant products are continuously being explored in medicine against free radicals induced oxidative stress and increasing No. of antibiotic resistant organisms. In the present study antioxidants and antimicrobial activity of methanol leaf extract of N. laevis and Crateva adansonii against some pathogenic microorganism were carried out. The antioxidants activities were conducted using DPPH radical scavenging assay. The antibacterial activity was screened against Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella typhi, Staphylococcus aureus and E. coli using agar well diffusion method at various concentrations (160, 120 and 80 mg mL–1). The Minimum Inhibitory Concentration (MIC) was determined using serial dilution method, while Minimum Bacterialcidal Concentration (MBC) by plating various dilution of extract. Results revealed the presence of alkaloid, flavonoids, saponins, terpenoids, glycoside and anthraquinone in methanol leaf extract of N. laevis. Newbouldia laevis and Crateva adansonii extracts and the standard antioxidant (Vitamin E) promoted an inhibition of DPPH radical with increasing concentrations. The IC50 values of C. adansonii, N. laevis and Vitamin E were 1562.52, 155.17 and 83.65 mg mL–1, respectively. The zone of inhibition demonstrated by the two extracts increase with increase concentration. The MIC of both extracts was in range of 120-160 mg mL–1, while the MBC range between 120-160 mg mL–1. It is concluded that N. laevis contains some useful phytochemicals with potential antioxidants and antibiotic reputations. Thus, it may be considered as a natural source of antimicrobials and antioxidants for therapeutic purposes.

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