Asian Network for Scientific Information is a leading service provider to the publishers of Science, Technology and Medicine (STM) in Asia. Currently Asian Network for Scientific Information is serving more than 37 peer-reviewed journals covering a wide range of academic disciplines to foster communication among scientists, researchers, students and professionals - enabling them to work more efficiently and intelligently, thereby advancing knowledge and learning.

Research Journal of Mutagenesis
eISSN: xxxx-xxxx
pISSN: 1994-7917

Editor-in-Chief:  Adel Sharaf Al-Zubairi
Current Issue
Guide for Authors
Editorial Board
Article Processing Charges
Research Article
Published on October 19, 2017
Evaluation of the Mutagenic Potential of Glucocorticoids by Allium cepa
Veronica Passos Cordeiro de Oliveira, Gabriela Rodrigues de Sousa, Mariana Petit Teofilo de Araujo, Lilian Carla Carneiro, Daniela Medeiros Lobo de Andrade, Hellen Karine Paes Porto, Monica de Oliveira Santos and Aroldo Vieira de Moraes Filho
Background and Objective: Corticosteroids are drugs used in the therapy of different types of diseases, such as respiratory, inflammatory, allergic, neoplastic and auto-immune diseases. The wide use of these drugs causes certain concerns related to their harmful effects on health. This work has the objective to evaluate the mutagenic potential of three widely used glucocorticoids (Prednisolone, Dexamethasone and Hydrocortisone) in Allium cepa meristematic root cells. Materials and Methods: The genotoxic potential of the corticosteroid drugs were evaluated using the dosages following the minimum, usual and maximum dosage standards of each of them, the doses being of 100, 1,000 and 2,500 mg for Hydrocortisone, doses of 0.75, 7.5 and 15 mg for Dexamethasone and doses of 5, 20 and 60 mg for Prednisolone, performed by the Allium cepa test. For statistical analysis, the ANOVA one-way test was used, with a significance level α = 0.05, using the statistical package, GrafPad Prism 5.0. Results: The results showed that all doses of the glucocorticoids analyzed induced a significant increase in the index of chromosomal aberrations in a dose-dependent manner, indicating genotoxic potential. Conclusion: According to the results, the corticosteroid called "betamethasone" presented genotoxicity and dose-dependent cytotoxicity.

Newsroom    |    Frequently Asked Questions    |    Privacy Policy    |    Terms & Conditions    |    Contact Us